Amazing storyline, great combat system, immersive gameplay, beautiful and breathtaking locations, one of the best and most shocking endings I've seen Cons: No multiplayer (made up for in Bioshock 2 though)
This game is the total package. Great graphics, in-depth game mechanics, dark foreboding environment. Quite possibly the best thing to happen as a result of "Atlas Shrugged". Cons: Loses it's challenge when you're decked out with plasmids and custom weapons. Especially during the endgame boss.