One of the world's great bookstores. They have a decent coffee shop; they sell new and used books; they fill several stories of a full city block (and still need *several* annexes); AND they shelve new and used books together!
Special note: If you're visiting from out of town, and go overboard (easy to do), they will even ship the books you buy there!
I try to make it in here every time I visit Portland. The food is generally local and interesting. The bar is fantastic, and keeps a top-notch array of whiskeys on hand, as well as offering a really solid cocktail list.
Also, it's just a few blocks from Powell's City of Books, always a plus.